Mitochondrial autophagy as a compensatory response to PINK1 deficiency
نویسندگان
چکیده
منابع مشابه
TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency
OBJECTIVE Loss of function mutations in PINK1 typically lead to early onset Parkinson disease (PD). Zebrafish (Danio rerio) are emerging as a powerful new vertebrate model to study neurodegenerative diseases. We used a pink1 mutant (pink(-/-) ) zebrafish line with a premature stop mutation (Y431*) in the PINK1 kinase domain to identify molecular mechanisms leading to mitochondrial dysfunction a...
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Although aging is a known risk factor for idiopathic pulmonary fibrosis (IPF), the pathogenic mechanisms that underlie the effects of advancing age remain largely unexplained. Some age-related neurodegenerative diseases have an etiology that is related to mitochondrial dysfunction. Here, we found that alveolar type II cells (AECIIs) in the lungs of IPF patients exhibit marked accumulation of dy...
متن کاملDJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.
Mutations in DJ-1, PINK1 (PTEN-induced putative kinase 1) and parkin all cause recessive parkinsonism in humans, but the relationships between these genes are not clearly defined. One event associated with loss of any of these genes is altered mitochondrial function. Recent evidence suggests that turnover of damaged mitochondria by autophagy might be central to the process of recessive parkinso...
متن کاملNeonatal mitochondrial abnormalities due to PINK1 deficiency: Proteomics reveals early changes relevant to Parkinson׳s disease
Parkinson׳s disease (PD), the second most common neurodegenerative disorder, affects roughly 7-10 million people worldwide. A wide array of research has suggested that PD has a mitochondrial component and that mitochondrial dysfunction occurs well in advance of the clinical manifestation of the disease. Previous work by our lab has categorized the mitochondrial disorder associated with Parkinso...
متن کاملPINK1 in mitochondrial function.
R are, inherited mutations causing familial forms of Parkinson’s disease (PD) have provided much insight into some of the molecular mechanisms that underlie both the genetic and sporadic forms of the disease. The role of mitochondria in sporadic PD has been debated for a little over 20 years, since the identification of complex I deficiency in the substantia nigra pars compacta (SNpc) (1). Howe...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2009
ISSN: 1554-8627,1554-8635
DOI: 10.4161/auto.5.8.10050